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Although the mechanisms involved in the modulation of synaptic plasticity by neurexins remain to be verified, it is important to note that they have a clear effect on synaptic plasticity and are candidates with sustained antidepressant potential

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Dabigatran etexilate is the first new oral direct anticoagulant after warfarin, which overcomes the difficulties of low bioavailability of warfarin and the need for drug monitoring, and has been recommended as an alternative to warfarin by the American Guidelines for the Treatment of Atrial Fibrillation [13]

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