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With respect to the phase I metabolizing enzymes, Cyp2e1 was among the most downregulated genes, which is plausible because this enzyme metabolically activates CCl 4 ( Cyp7b1 (Figure 3B), expression of Cyp7a1, a key enzyme in bile acid synthesis, was also decreased, although to a smaller degree than that of Cyp7b1 ( Supplementary Material)

An increasing amount of evidence has shown that the dysregulation of various specific miRNAs can cause impaired spermatogenesis and male infertility [130]