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It is important to note that HO-1-mediated ferroptosis has been shown to inhibit the progression of diseases such as glioblastoma, further revealing the potential therapeutic value of HO-1 in other pathological contexts (95)

SH-SY5Y cells and 6-OHDA-treated SH-SY5Y cells were incubated with 10 L Cell Counting Kit-8 (CCK-8) buffer (Dojindo, Japan) for 4 h to determine half maximal inhibitory concentration (IC 50 ) (Supplementary Figure S1) and optimal SJZD concentration, respectively

The genetic code of the active site seleno-cysteine is UGA, which is the same as the termination codon, thus requiring special seleno-cysteine-tRNA (Sec-tRNA) transport (Moosmann and Behl, 2004)