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Retatrutide's diabetes relevance comes from its incretin and glucagon receptor profile

C3a and C5a receptor antagonists ameliorate endothelial-myofibroblast transition via the Wnt/-catenin signaling pathway in diabetic kidney disease

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doi: 10.1038/nrc.2017.86 60 WillinghamSBVolkmerJ-PGentlesAJSahooDDalerbaPMitraSSet al

Tirzepatide is a dual glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist approved by the FDA for type 2 diabetes and chronic weight management