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2 The role of GFRA3 + C-fiber nociceptors in normal mechanical and cold sensation, and characterization of retrograde tracing neurons from ankle joint

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In line with its objectives, the review focuses on the discussion of in vitro studies and some animal models, without considering the possible contributions of clinical studies

Furthermore, nanodevices can be devised for microenvironment-specific treatment, such as acidosis, oxidative stress, and enzyme-specific release, ensuring controlled release of the drug in the site of injury