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When the fibrous striations are fully formed and elliptical, meaning that melanin synthesis has begun, enzymes such as TRP-1, TYR, and dopachrome tautomerase (DCT) are required to synthesise the phenolic amino acid precursor L-tyrosine into melanin [184]

Purging pimples often complete this cycle in seven to ten days

This pattern likely reflects their resistance to surface sterilization rather than their true abundance [83]