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The peptide operates through multiple complementary pathways that address the key limitations of natural healing in tendinous and ligamentous tissues

Larger chains may struggle to cross epithelial membranes because their physicochemical properties do not favor passive diffusion, and most are not transported efficiently through active transport pathways

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Adequate blood supply is critical for wound healing because blood delivers oxygen, nutrients, and immune cells to damaged tissue while removing waste products and dead cells

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The difficulty in translating the preclinical success of combined TGF and immune checkpoint inhibition to clinical trial