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To date, chemical compounds that inhibit several pathways deregulated in FXS represent the most studied approaches for FXS management

Abraham Kupfer (Johns Hopkins University) for kindly providing the D10 and CH12 cell lines

This research primarily focused on assessing changes in substance P, beta-endorphin, and corticosterone levels, which are critical in understanding the stress response and potential modulatory impacts of DSIP

Furthermore, natural products, such as polyphenols, terpenoids, and alkaloids, are likely converted by gut bacteria into bioactive metabolites that can activate the Nrf2/ARE pathway, enhancing the host's antioxidant capacity and contributing to the management of oxidative stress-related diseases

It is able to prevent damage to important cellular components caused by reactive oxygen species such as free radicals, peroxides, lipid peroxides, and heavy metals

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