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10.1016/j.peh.2021.100201 11 DeconinckE.VanheeC.KeizersP.GuinotP.MihailovaA.SyversenP

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A prudent path is to assess for folate sensitivity in the history and to quantify methylation statustypically with whole-blood histamine and a methylation pathway panel (SAM, SAH, homocysteine)before attempting high-dose folate