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3hyperreflexia, e.g., coiling flexor spasm and clonus in response to light touch or stretch

339 In terms of patient heterogeneity, the stage and pathological characteristics of the disease can impact treatment outcomes

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After optimizing sample acquisition, processing, and analysis, we applied this method to characterize Cys species in plasma from normal donors and patients with different diseases, and to monitor changes in plasma Cys redox state in an SCD patient being treated with N-acetylcysteine (NAC), an FDA-approved antioxidant drug