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In contrast, DFP treatment significantly decreased Fe 2+ levels in optic nerve tissue, downregulated TFR1 and Iba-1 expression, and inhibited iron deposition, ferroptosis, microglial activation, and astrocyte proliferation, thereby reducing myelin loss and optic nerve damage in MS mice (Rayatpour et al., 2022)

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Fabrini R, Bocedi A, Camerini S, Fusetti M, Ottaviani F, Passali FM et al

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