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Biochim Biophys Acta Mol Basis Dis (2021) 1867:166114

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found that cancer associated fibroblast (CAF) synthesize glutamine in glutamine-deficient tumor microenvironment to maintain glutamine-addicted ovarian cancer cell growth, where targeting glutamine synthetase in tumor stroma could reduce tumor weight and metastasis in orthotopic ovarian carcinoma mouse model, and the treatment effect can be further enhanced by co-targeting glutaminase in cancer cells (109)

The results of this study shows that: 1) based on the serum levels of urate salt gene, the lack of SLC22A12 was 10% more prominent in men than in women, and can be genetic (Misawa et al., 2020)

In three of four patients undergoing this sequential therapy, complete remission resulted

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