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Substantial evidence indicates that mutations in several PD-associated genes (e.g., LRRK2, GBA, PINK1, PRKN, *DJ-1*) and the expression of risk alleles such as APOE4 exert their pathological effects by disrupting autophagy-related pathways, notably the autophagy-lysosomal pathway and mitophagy (3)

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Nature 417 , 447452 (2002)

doi:10.1371/journal.pgen.1002947

Cre ERT2 is a recombinant fusion protein of the Cre DNA recombinase and a mutant ligand-binding domain of the human estrogen receptor