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Detoxification, however, is managed by the liver and kidneys

PMID: Summary Keywords adenosine, CD38, daratumumab, immunosuppression, immunotherapy, inosine, isatuximab, multiple myeloma Citation Horenstein AL, Frerichs KA, Faini AC, van de Donk NWCJ and Malavasi F (2026) Modulating CD38 enzymatic activity during antibody-based immunotherapy in multiple myeloma: a basic science perspective

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The larger the reserves, the greater the normal daily losses, and vice versa: the smaller the pool (reservoir) of cobalamins, the less B12 will be eliminated, which could be the result of a metabolic adaptation to low reserves