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Likewise, concanavalin A (Con A) induced liver injury may be also mediated by GSDME upon GzmB cleavage 33

Intriguingly, a similar observation was found in the astrocytes cluster, which also expressed typical OL-transcripts, such as Mobp , Mbp , and Rfn220 (Fig

Cell 64 , 859874 (2016)

Whether this hypothesis is correct or whether accessible disulfides (e.g., within an extended loop or a flexible N- or C-terminus) circumvent such steric limitations remains to be analyzed