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52 The resulting loss of functional ATP7A in the intestine leads to reduced Cu efflux into the blood, an accumulation of Cu in enterocytes, and generalized severe systemic Cu deficiency

Moreover, the intertwining of climate crisis and social inequalities increasingly calls for innovative and flexible interventions capable of dialoguing with the most advanced systems of cognitive automation and computational capacity

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This is particularly relevant because hypoxic tumours are known to exhibit increased resistance to radiotherapy and certain systemic therapies (190, 191), and therefore, imaging hypoxia has potential implications for treatment planning and prognostic assessment