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Research Findings (Summary) Among the 66 healthy adult men and women aged 45 to 70 who participated in the study, those with high-normal blood pressure at the start of the study showed significantly greater FMD, an indicator of vascular endothelial function, than the placebo group (Figure 1)

Purification and characterization of the acid-labile subunit of rat serum insulin-like growth factor binding protein complex

You need to go through the treatment for 6-8 weeks before you see significant results

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Golombek SK, May JN, Theek B, Appold L, Drude N, Kiessling F, et al

Arch Neurol 46:543548