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10.1016/j.biopha.2018.07.072 4 ChenH.GuoJ.ZhaoX.HeX.HeZ.ZhaoL.et al (2017a)

For the best results, a series of treatments may be recommended, typically spaced a week or two apart

Impact of KEAP1/STK11 co-mutations and NRF2 signaling on resistance to adagrasib in advanced NSCLC

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These findings are in agreement with previous reports showing that mTOR inhibition suppresses pro-inflammatory microglial activation and reduces astrocytic pro-inflammatory cytokine production [65, 66], supporting a role for autophagy in reducing pro-inflammatory cytokine production and microglial activation, thereby contributing to neuroimmune homeostasis