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Description

The therapeutic index based upon animal studies is small

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mTORC1 regulates cystine uptake through ATF4 Among the 61 shared mTORC1- and ISR-induced ATF4 gene targets identified, the cystine-glutamate antiporter Slc7a11 (xCT) was the most significantly induced gene upon insulin treatment (Figure 1F)

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Exact P -values for each comparison are available in Source Data

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X.ReznikovL.Abou AlaiwaM.ErnstS

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Oxidation of glucose and pyruvate, however, generates ATP by both substrate level and oxidative phosphorylation, generating more ATP per oxygen consumed

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Gastroenterology

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