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doi: 10.1186/s12916-019-1321-x

Melatonin may also alleviate cadmium-induced endoplasmic reticulum and cellular stress, regulate unfolded protein response, influence germ cell apoptosis, and prevent neurotoxic effects

Nrf2, a key player in this process, is responsible for the activation of the antioxidant response element and subsequent expression of antioxidant enzymes