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doi: 10.1210/er.2018-00006 29 FerrariSMFallahiPEliaGRagusaFRuffilliIPatrizioAet al

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Synthetic HGH bypasses this regulation entirely, which is one reason it carries a higher risk of adverse effects including acromegaly-like symptoms, significant glucose dysregulation, and IGF-1 overshoot

found that ipamorelin could stimulate the release of GH from primary rat pituitary cells and swine [9], and concluded that the peptide could be a very interesting candidate for future clinical development. A 2002 study published in the European Journal of Anatomy found that ipamorelin treatment could stimulate body weight gain and GH release in young female rats [12]