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Hyperuricemia is a condition characteristic for a multicellular organism and so the results may not obligatory be related to real pathophysiological conditions

GPX4 inactivation disrupts antioxidant defenses, impairs cellular clearance of lipid peroxides, and triggers iron-dependent lipid peroxidation chain reactions, ultimately inducing cellular ferroptosis (Chen et al., 2025

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Additionally, the mechanism by which these two factors synergistically regulate the proliferation of tumor cells warrants further investigation

proposed a synergistic strategy that combines oxygen-enhanced sonodynamic therapy with ferroptosis via engineered exosomes, demonstrating higher efficacy in anticancer treatment [154]