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10.1016/j.cjca.2021.02.009 199 TeringovaE.TousekP

Acta 58 EhrlichM.LaceyM

Epub 2023 May 6

Improved Membrane Permeability The cyclization of peptides contributes to the formation of intramolecular hydrogen bonds and the orientation of side chains, which in turn helps to protect polar atoms from solvent mediators, reduces intestinal, blood, and tissue degradation, decreases flexibility, reduces polar surface area, and facilitates the permeability of cell membranes

Additionally, it plays a key role in influencing the hypothalamus and pituitary gland, regions of the brain central to sleep and hormonal balance, further enhancing its impact on the sleep cycle