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The critical design choice was the C-terminal PGP extension: Pro-Gly-Pro provides primary resistance to proteolytic degradation, extending the compound's half-life from the minutes range of native ACTH(4-7) to approximately several hours, enabling meaningful and sustained CNS activity following administration

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Wu HG, Song SY, Kim YS, Oh YT, Lee CG, Keum KC, et al

Treatment of medulloblastoma cell lines with HGF induced tumor cell proliferation, anchorage-independent growth and reduced apoptosis in response to chemotherapy

Historical Background and Scientific Context Scientific interest in DSIP emerged during the twentieth century as researchers expanded their understanding of naturally occurring peptide signalling molecules and their role within complex biological systems

The action of the NL-GHK-Cu peptide allows for the restoration, maintenance, and protection of a properly functioning nervous system