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Statements Author contributions SAC: Writing review & editing, Conceptualization, Validation, Writing original draft, Supervision, Data curation

However, despite the complex interplay between coagulation and inflammation, activation of coagulation is not a prerequisite for cell injury or organ damage [22]

Considerable heterogeneity exists across studies with respect to microbiome sequencing technologies, bioinformatic analysis pipelines, and population characteristics, which may contribute to inconsistencies in reported microbial signatures