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Pourmadadi M, Abbasi P, Eshaghi MM et al (2022) Curcumin delivery and co-delivery based on nanomaterials as an effective approach for cancer therapy

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However, DAMPs alone are insufficient to explain the initiation of PEM, especially in post-infectious syndromes such as PCC, where PAMPs may play a crucial role ( 3.1 Mitochondria-driven inflammatory signaling Mitochondrial dysfunction may lead to the overproduction of ROS and the release of mtDNA into the cytoplasm (108110), which subsequently may activate the NLRP3 inflammasome (111, 112)

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These processes are driven by the activation of the epidermal growth factor receptor (EGFR) and the ERK1/2 MAPK signaling pathway

Ethics statement The studies involving human participants were reviewed and approved by the Institutional Review Boards at American University and Georgetown University