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Oncogene 19 , 49474953 (2000)

Direct reprogramming without entering pluripotent cell state shortens the time for cell differentiation and lower the risks of tumorigenesis, which is deemed as a promising method to yield hepatocytes for HTx

The gut-barrier connection here is central: intestinal permeability (leaky gut) and immune dysregulation arent separate problems

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More recent research published in Frontiers in Pharmacology (2021) demonstrated accelerated wound healing in animal models through increased blood flow and collagen repair