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An enzyme complex of nitric oxide synthases (NOSs) consisting of neuronal NOS type 1, inducible NOS (iNOS) type 2, endothelial NOS (eNOS) type 3 and mitochondrial NOS (mtNOS) catalyzes the synthesis of various nitrogen products [13]

Such system can improve the efficacy of artemisinin and present a promising strategy in the treatment of lung, colon, and breast cancers [163,164,165]

32 , 16261635 (2021) C

doi 10.3390/biom15010085

However, several studies have shown an increase in the level of glutamate in ACC of depressed subjects (106, 111), hippocampus of MDD subjects with alcoholic tendencies (115), and CSDS model of depression in mice

ROS include superoxide anion (O2-), hydroxyl radical (OH), hydrogen peroxide (H2O2), and singlet oxygen (1O2) [10]