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6.4.2 The role of self-immolative spacers For payloads that diminish efficacy with modest structural alterations, self-immolative spacers (e.g., p-aminobenzyloxycarbonyl or PAB) function as a chemical disappearing act. These spacers are positioned between the cleavage site and the drug

This is seen in the use of SSRIs and antidepressants for anxiety and depressive states, lithium and tamoxifen in bipolarity, where pre-clinical studies show downregulation of PKC activity and clinical data show improved outcomes

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In contrast, glutathione (GSH) levels were significantly decreased in the midbrain (Figure 1G)

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