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By using a linker that is too short to allow pairing between the two domains on the same chain, the domains are forced to pair with the complementary domains of another chain and create two antigen-binding sites

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Goenrich M, Bartoschek S, Hagemeier CH, Griesinger C, Vorholt JA

doi:10.1158/1940-6207.CAPR-13-0261

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