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FTY720 (fingolimod) efficacy in an animal model of multiple sclerosis requires astrocyte sphingosine 1-phosphate receptor 1 (S1P1) modulation

For example, the frequency of spontaneous excitatory synaptic transmission (EPSCs) in the primary culture of hippocampal neurons of Mecp2 -KO mice was significantly decreased [376]

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doi: 10.1016/j.biopha.2020.110022 132 PetrasekJIracheta-VellveACsakTSatishchandranAKodysKKurt-JonesEAet al

The G s protein stimulates the increase of cyclic AMP (cAMP) levels by activating adenylyl cyclase, while G i inhibits cAMP levels (79)