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PMC 4385258

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doi: 10.1038/sj.onc.1207844 179 GurneyAAxelrodFBondCJCainJChartierCDoniganLet al

To explore the mechanism behind this crosstalk, the researchers examined the diffusivity of Rho GTPases during sLTP and showed that RhoA and Rac1 had a higher diffusion distance than Cdc42, that is, the active RhoA, and Rac1 diffused to the nearby spines whereas the active Cdc42 remained locally in the activated spine

[Epub ahead of print] [PubMed: 23011167] (Analysis of a prospective study of iv vs oral acetylcysteine therapy of acetaminophen overdose identified 37 patients who weighed more than 100 kg of whom 34 received a weight-based dose, although recommendations are for a maximum dose based on a maximum weight of 100 kg [iv] or 110 kg [oral])

On the other hand, in DS, the total amount of both A40 and A42 increases due to the increased copy number of APP caused by extra chromosome 21