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Precursors of GSH or GPX biosynthesis, various small molecule activators related to the GSH system and some novel therapeutic approaches, such as exosomes and gene therapy, can boost the activity of the GSH system and reduce cardiac damage and ferroptosis

At this point it cannot be ruled out that some of the proteins that were captured with monothiol glutaredoxin mutants as Grx(SSR) species might have just accumulated as unspecific dead-end products

A key unresolved question is whether compartment-specific GSH pools differentially determine ferroptosis initiation at mitochondrial versus non-mitochondrial membranes

Androgen receptor contributes to microglial/macrophage activation in rats with intracranial hemorrhage by mediating the JMJD3/Botch/Notch1 axis