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There is a lack of data from large-scale clinical trials to validate its safety and efficacy, as well as to clarify its dosage range and time window for clinical application

These metabolites exert biologically relevant effects of their own and have greater bioavailability than their parent polyphenolic compounds (20), representing a likely mediator of polyphenols effect on health outcomes, including on sleep health

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Researchers should exercise caution and document all parameters carefully

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