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doi: 10.1016/S0141-0229(85)80001-6 106 EdiriweeraA

This process can be also elicited modulating cellular sensitivity through the cystine/glutamate antiporter (system Xc-) suppression, acting on their intracellular concentrations, or reducing the activity of GLS2, the enzyme catalyzing the conversion of glutamine into glutamate [31]

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These events occur at a high frequency in tumor mtDNA and tend to accumulate within specific hypervariable regions, such as the D-loop [143]

Interestingly, recent studies have shown that melatonin is an important and essential hormone during pregnancy, specifically in the placenta

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