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Among the most studied antioxidants are N-acetylcysteine (NAC), resveratrol, vitamin E, and alpha-lipoic acid, each of which has demonstrated significant potential in strengthening the BBB in preclinical models of neurodegenerative diseases [211,212]

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Reczko et al, 2012)

Wei SB, Cao YF, Wang Y

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Nevertheless, multivariate analyses of NMR results failed to discriminate iPD from gPD (Marino et al., 2025a) or rvPD patients (Marino et al., 2025b), even after sex stratification (Marino et al., 2025a, 2025b), indicating shared metabolic abnormalities across PD subtypes, likely driven by common disease-related mechanisms