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The initial reaction rates at different concentrations of compound were used to determine EC 50 values, which were calculated with a four-parameter logistical model of log dose against percentage activation and were obtained from at least three sets of experiments

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Metabolome changes in cerebral ischemia

Nanomaterials, 10 (2), Article 264

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In the same study, it was reported that chlamydocin inhibits HDAC with an IC 50 value of 1.3 nM and the antiproliferative activity was found to be accompanied by an increase in the accumulation of the acetylated histones H3 and H4, the induction of p21 Wafi/Cip1 , and cell cycle arrest in the G 2 /M phase (Schepper et al., 2003)