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Conversely, experimentally forcing a diapause-like state by deleting the histone acetyltransferase (HAT) males absent on the first (MOF, KAT8/MYST1) in naive mESCs diminishes FAO gene expression (through loss of H4K16ac at those loci) and triggers a quiescent pluripotent state akin to diapause, which can be partially rescued by providing fatty acid substrates 28

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This adaptation is not a sign of reduced efficacy