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In animal models, decreased epithelial resistance has been shown to precede microscopic inflammation [151]

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Sterile water for injection is a single-use product: once the vial seal is broken, the absence of any preservative means that microbial contamination can occur with each subsequent access, making it unsuitable for the repeated needle access that is typical in peptide stock solution workflows

Furthermore, Keap1 collaborates with the chaperone proteins, heat shock proteins (HSPs) [92], and tripartite motif-containing proteins (Trims) [93] to regulate NLRP3 ubiquitination and degradation