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When it does happen, you usually have another condition such as: Endocrine disorders, such as Addison's disease, Cushing's syndrome, and hyperthyroidism Lupus Metabolic disorders, such as alcaptonuria Hyperbilirubinemia (in which you can't break down bilirubin) Rare genetic problems, such as porphyria, Touraine syndrome, or Laugier-Hunziker syndrome Tumors Active melanocytes can form longitudinal melanonychia because of noncancerous and cancerous tumors

doi: 10.4103/0973-7847.70902 69 CardDJGorskaRHarringtonDJ

The endothelium is the delicate, single-cell layer lining the inside of all blood vessels

The adequacy of model assumptions was investigated by residual plots (Hartig, n.d.)

BRCAness, SLFN11, and RB1 loss predict response to topoisomerase I inhibitors in triple-negative breast cancers