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Induction increases the elimination clearance of a xenobiotic or endogenous compound, thus reducing steady state levels and makes optimization of dosing more difficult

Electrolyte Imbalances: Provides tailored solutions to restore essential minerals like sodium, potassium, or magnesium

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Controlled release formulations: Designing for slow, controlled release can prevent high levels of toxicity (267), while ensuring sustained nutrient availability throughout critical growth period

10.1016/j.jalz.2015.04.011 172 MukhopadhyayD.Arranz-SolsD.SaeijJ