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NFAT5 (TonEBP), as a key osmosensing transcription factor, participates in differentiation regulation by modulating Sox9 ( In summary, the IVD hyperosmotic environment typically inhibits cell growth and anabolism, but a moderate increase in osmotic pressure may induce chondrogenic/NP-like differentiation

Targeting Metabolic Symbiosis to Overcome Resistance to Anti-angiogenic Therapy

Sep-Oct 2003;54(5):531-9

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