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Brasky TM, White E, Chen CL

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A short pharmacological interruption of the RA signaling in adult mice leads to a decrease in airway function, an increase in airway smooth muscles (ASM) thickness, and collagen disposition, resulting in ASM hypertrophy and airway remodeling [228,229]

Because treatment data for this condition are difficult to interpret in the absence of a placebo control, bodies of evidence comprised entirely of studies that lacked placebo control groups (i.e., observational studies) were assigned a strength rating of Grade C

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