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Perillyl alcohol attenuates rheumatoid arthritis via regulating TLR4/NF-B and Keap1/Nrf2 signaling pathways: A comprehensive study onin-vitro and in-vivo experimental models

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Nature Metabolism 1(11):1074-1088

Daily intraperitoneal administration for 11 days reduced body weight gain, decreased white adipose tissue mass by approximately 35%, and reduced adipocyte size, while food intake between treated and control groups did not differ significantly

This is achieved through receptor phosphorylation by kinases like G protein-coupled receptor kinases (GRKs) and subsequent binding of arrestins, which inhibit further G protein activation