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Once exposed to room temperature for extended periods, the vial should not be returned to refrigerated storage and used beyond the 21-day window

If concentrations of serum vitamin B12 are above the reference range and people have no specific medical conditions, the panelists agreed that inquiring about the usage of supplemental vitamin B12, repeating the measurements of serum B12 after a given time interval, and measuring routine blood markers of renal or liver function or exploring malignancies [91] could explain the cause of high serum B12 (Table 1)

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Cell 162 (6), 12991308