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This is supported by findings in bone marrow-derived macrophages, where treatment with RBCs to induce EP resulted in a marked increase in HO-1 expression (approximately 10-fold) (87)

The authors found that treatment with Mdivi-1(inhibitor of Drp-1) could ameliorate intraretinal microvascular abnormalities, including, retinal vascular leakage, avascular capillaries and apoptosis in the streptozotocin model of diabetes in SpragueDawley rats (Zhang et al., 2022)

Hughey, Martin Joyce-Brady)

It is worth noting that HO-1 may have the potential for preventing colitis by regulating macrophage polarization [145]

Tumors with increased BACH1 expression may show a greater sensitive to ferroptosisinducing drugs compared to those with decreased levels, and further experimentation is required for validation

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