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Description

Apart from the receptor-dependent hormone signaling, certain metabolites of estrogens act as direct carcinogens, such as the catechol 4-hydroxyestradiol and its derivative quinones [148]

This feature allows ectopic endometrial cells to evade clearance and proliferate within the ectopic environment ( Research indicates that resistance to apoptosis in EMs manifests as a synergistic dysregulation of dual pathways

Experiences and results of 344 cases]

K.ChatterjeeS.RayM

Int J Mol Sci (2017) 18(5):E1033.10.3390/ijms18051033 119 PlitasGRudenskyAY

Moreover, both Vilda and DHA significantly increase gene expression of SIRT1, Akt, and PI3K and markedly restored normal pancreatic tissue architecture compared with diabetic control group