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These effects were attributed to elevated ACh and choline acetyltransferase (ChAT) levels in the serum and hypothalamus, promoting better neuronal communication and reduced apoptosis ( 2.13 SAMP8 mice and 5FAD mice insights in Alzheimers disease research The identification of mutations linked to familial AD has provided critical insights into the fundamental mechanisms underlying disease pathogenesis and progression

Keywords: methylmercury, neurotoxicity, oxidative stress, glutamate, calcium, selenium, selenoproteins, glutathione peroxidase Introduction Neurological disorders represent an important health concern faced by society, accounting for great numbers of hospitalizations and disabilities (Schmidt, 2007)

Secretagogue studies often run over many weeks before measuring body composition changes

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15 An early report has indicated that glutamate toxicity in a neuronal cell line is triggered by inhibition of cystine transport, leading to oxidative stress