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Furthermore, while multiple motors may associate with secretory granules, in vivo studies indicate that only a single motor is actively engaged at a given time [86, 87]

J Eval Clin Pract 14:951957

[11] It is also an important therapy and steroid-sparing agent for inflammatory bowel disease (such as Crohn's disease and ulcerative colitis) and for multiple sclerosis

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The sublingual epithelium simply cannot accommodate the passage of larger molecules through either paracellular or transcellular routes without assistance from permeation enhancers