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J Biol Chem (2015) 290:2902

It is tempting to speculate that the high susceptibility of -enolase to modification by HNE and other aldehydes might be instrumental for its involvement in autoimmunity as an oxidatively modified self antigen, capable of breaking the immunological tolerance of autoreactive T and B cells

Sci Signal (2015) 8:ra97

The selective ULK1/2 inhibitor, DCC-3116, synergizes with the KRASG12C inhibitor sotorasib to suppress KRAS-driven LC, whereas this combination has been assessed only in early preclinical stages and lacks predictive biomarkers for patient stratification (17)

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PD is among these disorders and its treatment is currently focused solely on symptom elimination